Background Intratumoral heterogeneity (ITH) and subclonal antigen expression blunt antitumor immunity and are associated with poor responses to immune-checkpoint blockade immunotherapy (ICB) in patients with cancer.The underlying mechanisms however thus far remained elusive, preventing the design of novel treatment approaches for patients with high

In this paper, a multi-region dynamic economic dispatch model with power balance constraint is constructed to seek the actual reserve demand and reasonable reserve allocation method of the system by relying on the dynamic response process of the units to the power balance of the interconnected system.For this kind of dynamic optimization problem wi

The continued development of intraocular lens (IOL) technology has led to a dramatic improvement in refractive outcomes.New and innovative ways of achieving the desired postoperative refractive goals continue to be developed.This article aims to review the currently available IOL modalities for correction of presbyopia at the time of cataract surge

This paper quantifies the benefits of flattening the curve (with a constant total patient load over the study period) on the risk of a hospital bed shortage in a pandemic.Using discrete-event simulation of patient care paths in hospitals, synthetic data that eliminates issues of confounding affects from the simultaneous occurrence of regional respo